The Journal of Neuroscience, December 17, 2003, ():
Subunit Phosphorylation Selectively Increases Fast Desensitization and Prolongs Deactivation of 
11
2L and 132L GABAA Receptor Currents
J. Neurosci.
Hinkle and Macdonald 23 (37): 11698.
HTML Page - index.htslp
Files in this Data Supplement:
- Supplemental Table A -
Desensitization and deactivation time constants for GABAA currents (6 sec)
Data in this and subsequent tables are expressed as mean ± SEM. In this and subsequent tables, t1, t2, t3 and tD are in msec and A1, A2, A3 and C are in %. All experimental groups were cultured with 10% FBS, and all statistical comparisons were made to the wild type control (bold) with the same _ subunit as the comparison group. Statistical significance was indicated by asterisks (* p < 0.05, ** p < 0.01, *** p < 0.001)
- Supplemental Table B -
Desensitization and deactivation time constants for GABAA currents (400 msec)
All experimental groups were serum-fed, unless otherwise indicated to be serum-starved. All statistical comparisons except those for forskolin treated cells were made to the wild type control (bold) with the same _ subunit as the comparison group. For those experiments, statistical significance was indicated by asterisks (* p < 0.05, ** p < 0.01). For statistical analysis, the forskolin group was compared to a subset of the serum-starved _1_3_2L control group that was comprised of paired control observations made with the same cell (paired t-test). Statistical significance for the forskolin group was indicated with plus signs (+ p < 0.05).
- Supplemental Table 3 -
Deactivation time constants for rapid application GABAA currents and simulated currents (5 msec)
All experimental groups were cultured with 10% FBS, and all statistical comparisons were made to the wild type control (bold) with the same the comparison group. To aid comparison with longer duration experiments, the weighted deactivation time constant (_D) calculated from the individual _1 and _2 deactivation time constants listed was included in the table. Statistical significance was indicated by asterisks (* p < 0.05, ** p < 0.01). Since SEMs in experimental groups are an indication of the intercell variability that does not exist in simulated data, simulations are shown without SEMs. All data were simulated using the Haas and Macdonald model (Haas et al., 1999). df and di were rates of entry into fast and intermediate microscopic desensitization states, respectively; while koff was the GABA unbinding rate (Figure 9A, B)
