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Erratum for Baumann et al., J. Neurosci. 23 (35) 11158-11166.
The Journal of Neuroscience, December 17, 2003, 23(37):11778

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ERRATUM

In the article "Individual Properties of the Two Functional Agonist Sites in GABA_A Receptors," by Sabine W. Baumann, Roland Baur, and Erwin Sigel, which appeared on pages 11158-11166 of the December 3, 2003 issue, several equations were set incorrectly because of a printer's error. The errors are located on page 11159, right column, beginning on lines 15 and 50, respectively. For the equation starting on line 15, the correct version is as follows:

"loose subunits, I(c) = [100 · (1 + L)]/[(1/{1 + (L₁ · K₁)/(L₂ · K₂) + (L₁ · c)/(L · K₂)}) · (1 + {K₁ · L₁}/c + L₁ + {L₁ · K₁}/K₂ + {c · L₁}/K₂ + {L₁ · K₁}/{L₂ · K₂} + {c · L₁}/{K₂ · L})]; for receptors linked /, I(c) = [100 · (1 + fA · L)]/[(1/{1 + (L₁ · K₁)/(L₂ · K₂) + (fa · L₁ · c)/(fA · L · K₂)}) · (1 + {K₁ · fa · L₁}/c + fa · L₁ + {fa · L₁ · K₁}/K₂ + {c · fa · L₁}/K₂ + {L₁ · K₁}/{L₂ · K₂} + {c · fa · L₁}/{K₂ · fA · L})]; for receptors linked /, I(c) = [100 · (1 + fG · L)]/[(1/{1 + (L₁ · K₁)/(L₂ · K₂) + (fg · L₁ · c)/(fG · L · K₂)}) · (1 + {K₁ · fg · L₁}/c + fg · L₁ + {fg · L₁ · K₁}/K₂ + {c · fg · L₁}/K₂ + {L₁ · K₁}/{L₂ · K₂} + {c · fg · L₁}/{K₂ · fG · L})]; for / receptors mutated in site 1 and an analogous equation for the mutation in residue ₁65 in site 1, I(c) = [100 · (1 + fA · L)]/[(1/{1 + (L₁ · K₁205)/(L₂ · ta205 · K₂) + (fa · L₁ · c)/(fA · L · ta205 · K₂)}) · (1 + {K₁205 · fa · L₁}/c + fa · L₁ + {fa · L₁ · K₁205}/{ta205 · K₂} + {c · fa · L₁}/{ta205 · K₂} + {L₁ · K₁205}/{L₂ · ta205 · K₂} + {fa · L₁ · c}/{fA · L · ta205 · K₂})]; for / receptors mutated in site 2 and an analogous equation for the mutation in residue ₁65 in site 2, I(c) = [100 · (1 + fA · L)]/[(1/{1 + (L₁ · ta205 · K₁)/(L₂ · K₂205) + (fa · L₁ · c)/(fA · L · K₂205)}) · (1 + {ta205 · K₁ · fa · L₁}/c + fa · L₁ + {fa · L₁ · ta205 · K₁}/K₂205 + {c · fa · L₁}/K₂205 + {L₁ · ta205 · K₁}/{L₂ · K₂205} + {fa · L₁ · c}/{fA · L · K₂205})]; and for / receptors mutated in both sites, I(c) = [100 · (1 + fG · L)]/[(1/{1 + (L₁ · K₁65)/(L₂ · K₂65) + (fg · L₁ · c)/(fG · L · ta65 · K₂65)}) · (1 + {ta65 · K₁65 · fg · L₁}/c + fg · L₁ + {fg · L₁ · K₁65}/K₂65 + {c · fg · L₁}/{t65 · K₂65} + {L₁ · K₁65}/{L₂ · K₂65} + {c · fg · L₁}/{ta65 · K₂65 · fG · L})]; I is the current, K₁ and K₂ are dissociation constants for agonists of the unmutated and K₁65,.... "

For the equation starting on line 50, the correct version is as follows:

"Inhibition was fitted with the equation I(c) = I_max /[(1/{1 + (L₁ · K₁)/(L₂ · K₂) + (L₁ · c)/(L · K₂)}) · (1 + {K₁ · L₁}/c + L₁ + {L₁ · K₁}/K₂ + {c · L₁}/K₂ + {L₁ · K₁}/{L₂ · K₂} + {c · L₁}/{K₂ · L} + {(b · K₁ · L₁)/c} · {1/K_1i + 1/K_2i + b/(K_1i · K_2i)})] for loose subunits, I(c) = I_max /[(1/{1 + (L₁ · K₁205)/(L₂ · ta205 · K₂) + (fa · L₁ · c)/(fA · L · ta205 · K₂)}) · (1 + {K₁205 · fa · L₁}/c + fa · L1 + {fa · L₁ · K₁205}/{ta205 · K₂} + {c · fa · L₁}/{ta205 · K₂} + {L₁ · K₁205}/{L₂ · ta205 · K₂} + {fa · L₁ · c}/{fA · L · ta205 · K₂} + {(b · K₁ · fa · L₁)/c} · {1/(m · K_1I) + 1/(tb205 · K_2I) + b/(m · K_1i · tb205 · K_2i)})] for / receptors mutated in site 1,.... "

This article has been cited by other articles:

				D. R. Burt Alpha Subunit Position and GABA Receptor Function Sci. Signal., February 8, 2005; 2005(270): pe5 - pe5. [Abstract] [Full Text] [PDF]

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