The Journal of Neuroscience, May 1, 2003, ():
Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment
J. Neurosci.
Blalock et al. 23 (9): 3807.
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Files in this Data Supplement:
- Supplementary Table 3 -
The number of ACRGs in each category is shown in parentheses after the category name and the parenthetical descriptor after the category name refers to characteristics of a majority of genes. GenBank- GenBank accession number; Name-gene name if known (asterisk indicates no gene name); Description- abbreviated description of gene, and/or gene product; Young, Mid, and Aged are Mean ± SEM of expression values across the three age groups (n = 9/10 group); ANOVA- p-value for 1-way ANOVA across age; Bhvr- Behavioral tasks for which Pearson’s correlation across all animals (N=29) was significant. ACRGs are ranked first by those correlated with Both tasks and then by ANOVA p-values. Asterisks in Bhvr also indicate correlation in the Aged group alone.
- Supplementary Table 4 -
The number of ACRGs in each category is shown in parentheses after the category name and the parenthetical descriptor after the category name refers to characteristics of a majority of genes. GenBank- GenBank accession number; Name-gene name if known (asterisk indicates no gene name); Description- abbreviated description of gene, and/or gene product; Young, Mid, and Aged are Mean ± SEM of expression values across the three age groups (n = 9/10 group); ANOVA- p-value for 1-way ANOVA across age; Bhvr- Behavioral tasks for which Pearson’s correlation across all animals (N=29) was significant. ACRGs are ranked first by those correlated with Both tasks and then by ANOVA p-values. Asterisks in Bhvr also indicate correlation in the Aged group alone.
- Supplementary Table 5 -
Genes are grouped according to direction of change with aging (A = Decrease from Young to Age; B = Increase from Young to Age; C = Decrease at the mid-aged time point, but reversed with aging; and D = Increased at the mid-aged point, but reversed with aging). Within each category, genes are sub-categorized according to the behavioral tasks with which they correlated (1 = Correlatedd with Both SWM and OMT; 2 = Correlatedd with OMT only; 3 = Correlated with SWM only; or 4 = did not Correlated with SWM or OMT). GenBank- GenBank accession number; Description- Affymetrix annotated description of gene (edited for brevity); Young/ Mid/ Aged- Mean ± SEM; FC- maximum fold change among the means from the three age groups; ANOVA- p-value for 1-way ANOVA across age; OMT/ SWM- p-value for Pearson’s correlation test between gene expression level and performance on the relevant behavioral task.
