The Journal of Neuroscience, May 5, 2004, ():
CD4-Positive T Cell-Mediated Neuroprotection Requires Dual Compartment Antigen Presentation
J. Neurosci. Byram et al.
24: 4333
Supplemental data
Supplementary Figure
Files in this Data Supplement:
- Supplementary Fig. 1
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Supplemental Figure 1. Experimental design for BM chimera studies. WT and MHC II KO mice were subjected to a lethal dose of whole-body irradiation and subsequent BM transplant. MHC II KO mice received WT-derived BM, resulting in an MHC II KO-chimera containing MHC II-negative resident microglial cells and MHC II-positive BM-derived APCs. WT mice received MHC II KO-derived BM, resulting in a WT chimera containing MHC II-positive resident microglial cells and MHC II-negative BM-derived APCs. One week before facial nerve injury, each chimera model was reconstituted with naive CD4+ T cells (from the lymph nodes of WT mice), activated CD4+ T cells (from cervical lymph nodes of WT mice 3 d after facial nerve axotomy), or no reconstitution (none).
