The Journal of Neuroscience, July 14, 2004, ():
Behavioral State Instability in Orexin Knock-Out Mice
J. Neurosci. Mochizuki et al.
24: 6291
Supplemental data
Supplemental figures
Files in this Data Supplement:
- Supplemental Fig. 1
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Figure 1. Orexin KO mice have cataplexy during active wakefulness. A, This representative episode of cataplexy demonstrates the sudden decrease in EMG activity and increase in EEG theta power. B, An expanded view of the 2 min period highlighted in A shows that EMG activity disappears over several seconds and then reappears abruptly. Rhythmic theta activity predominates during cataplexy and is preceded and followed by faster, mixed frequencies.
- Supplemental Fig. 2
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Figure 2. Sleep deprivation increases EEG delta power during NREM sleep in WT and orexin KO mice.. EEG delta power is expressed in 2 hr bins as a percentage of each animal’s mean NREM sleep delta power during the 24 hr baseline day. On the baseline day, both groups show the same time course of delta power (genotype [times] time, F = 1.66; p = 0.09). After 2-8 hr of sleep deprivation, WT and orexin KO mice have similar increases in delta power that decline over the first several hours of the recovery period, except that, after 4 hr of sleep deprivation, orexin KO mice have slightly lower delta power just at the beginning of the dark period (genotype [times] time, F = 3.77; p [lt] 0.01). *p [lt] 0.05; **p [lt] 0.01 compared with the baseline day. †p [lt] 0.05 compared with WT mice.
