The Journal of Neuroscience, September 1, 2004, ():
Hippocampal Plasticity across Multiple Days of Exposure to Novel Environments
J. Neurosci. Frank et al.
24: 7681
Supplemental Information
Files in this Data Supplement:
- Supplemental Fig. 1
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Supplemental Figure 1. Examples of the optimal polynomial fit. Each plot shows the normalized spatial area in blue and the optimal polynomial fit in red. The fits tend to be conservative, in that the derivatives of fast changes tend to be underestimated by the fit.
- Supplemental Movie 1
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Supplemental Movie 1. Example of the cell from Figure 2A cell showing rapid place field formation. The bottom plot shows the temporal intensity function, the middle plots shows the spatial intensity functions for the trajectories from the center arm (positions 0 – 60 cm) to the familiar left arm (positions 90 – 150 cm), and the top plots shows the spatial intensity functions for the trajectories from the center arm (positions 0 – 60 cm) to the novel right arm (positions 90 – 150 cm). In the middle (top) plot yellow (light green) represents the spatial intensity corresponding to head directions in the outbound direction while orange (dark green) represents the spatial intensity corresponding to head directions in the inbound direction. The white dot represents the animal’s position, and the vertical white lines represent the locations of spikes (spatial intensity) and the interspike intervals at which spikes occur (temporal intensity). The time, in seconds, is shown in the top left corner. The learning rates used for this simulation were the same as those used for all analyses (spatial 3.0 and temporal 0.05). The novel region of the track is represented in right hand section of the top graph at positions from approximately 90 cm to 150 cm. There is initially no activity in this region, but a place field appears in both directions of motion in the novel arm between a time of 240 and 270 seconds. The place field in the outbound direction continues to grow throughout the much of the rest of the exposure, but remains in the same spatial location, while the place field in the inbound direction is smaller and stabilizes more quickly.
