The Journal of Neuroscience, September 1, 2004, ():
Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease
J. Neurosci. Canals et al.
24: 7727
Supplemental Information
Files in this Data Supplement:
- Supplemental Movie 1
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Supplemental video. Low levels of BDNF produce more severe motor disturbances in mutant htt mice. Thirty-week-old R6/1 mice have minor alterations in rest. However, bDM show exacerbated chorea and tremors. Note the bradykinetic movements and tremors in bdnf+/- httm mice. Arrow and circle indicate leg dystonia and rigidity.
