The Journal of Neuroscience, October 27, 2004, ():
Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging
J. Neurosci. Jenkins et al.
24: 9553
Supplemental data
Out of the ten monkeys that were treated with MPTP, two displayed anomalous maps
after amphetamine administration. The first animal did not develop overt Parkinsonian
symptoms and showed a decrease in 11C-CFT binding potential of only 27%. This animal
maintained a robust rCBV response to amphetamine in all brain regions, but also showed
increased activation in primary motor and pre-motor areas as shown in Figure S1. A
second animal in spite of being Parkinsonian and having a 11C-CFT binding potential
decreased by 63% still showed a robust response to amphetamine as shown in Figure S2.
This animal also showed a very robust behavioral response to L-DOPA. Unlike the
partially lesioned animal showed in Fig. S1, this animal showed no rCBV response in the
substantia nigra. These data point out the possibility that the amphetamine challenge may
prove predictive of response to L-DOPA.
Files in this Data Supplement:
- Adobe PDF - Supp-Mat.pdf
- supplemental material
-
Supplementary Figure 1 - A statistical parametric map (t-test; top) of significant rCBV
increases in a partially lesioned macaque at 2.5 mg/kg amphetamine. This animal showed
only small behavioral effects and had a 27% decrease in 11C-CFT binding potential. The
phMRI images show increased recruitment of motor cortex (white arrows) not seen in
either the control or fully-lesioned animals.
- supplemental material
-
Supplementary Figure 2- A statistical parametric map (t-test; top) of significant rCBV
increases in an MPTP-treated macaque at 2.5 mg/kg of amphetamine. This animal was
parkinsonian (UPDRS score = 16) and had a decrease in 11C-CFT binding potential of
63%. A repeat phMRI study showed a similar pattern. This animal had a large increase
of CBV in the pre-motor cortex (white arrows). There was, however, a marked loss of
rCBV changes in SN (white circles). Interestingly, this animal showed complete reversal
of parkinsonian signs with low doses of L-DOPA suggesting that preservation of striatal
rCBV changes in response to amphetamine might indicate compensatory adaptive
mechanisms in the circuitry.
