The Journal of Neuroscience, December 8, 2004, ():
Tumor Necrosis Factor Receptor 1 and Its Signaling Intermediates Are Recruited to Lipid Rafts in the Traumatized Brain
J. Neurosci. Lotocki et al.
24: 11010
Supplemental data
Files in this Data Supplement:
- supplemental material
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Model of lipid raft mediated TNFR1 signaling after TBI. In a normal rat brain low levels of TNFR1 are present in lipid rafts and are in complex with TRADD, TRAF1, TRAF2, RIP and cIAP-1 and signals survival. Early after TBI, increased levels of TNFR1 recruit into lipid raft microdomains (.), where they associate with the adaptor protein TRADD, FADD, TRAF2, TRAF1, and cIAP-2. TNFR1 and TRAF1 are polyubiquitinated (Ubq(n) in lipid rafts after TBI, which leads to degradation via the proteasome pathway. In later stages after TBI, RIP and cIAP-1 appear to dissociate from TNFR1 complex by an unknown mechanism, and this complex signals death by activating caspase-8.
