The Journal of Neuroscience, February 4, 2004, ():
Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult
J. Neurosci. Kraft et al.
24: 1101
Supplemental data
Supplemental tables
Files in this Data Supplement:
- Supplemental Table 2
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tBHQ-induced genetic changes in astrocyte-enriched populations and Nrf2-dependence.
[Basal=signal of the vehicle-treated population; Fold=fold change of 10?M tBHQ compared to vehicle with standard error (SEM); CV=coefficient of variation; R=Rank from 4 comparisons (2x2 matrix); DN=effect of 50 MOI ad-DN-Nrf2 on gene expression changes induced by tBHQ. Gene functions were assessed using SwissProt and PubMed searches]. (N/R indicates that the gene did not pass rank; *the gene was significantly inhibited by DN, but still passed rank; if other than N/R, the fold change in the presence of DN is shown). Genes of interest that did not pass FC (?1.5 increased or 3 decreased) or had a CV?1.0 have the values shown in bold. Gene names in bold indicate genes that have already been shown or postulated to be ARE-driven (Rushmore, 2002; Moehlencamp et al., 1999; Lee et al., 2003; Li et al., 2002a; Murphy et al., 1991 and 2002; Shih et al., 2003).
- Supplemental Table 3
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Table 3: tBHQ-induced changes in neurons from mixed cultures and the requirement for Nrf2.
[Basal=signal of the vehicle-treated population; Fold=fold change of 10?M tBHQ compared to vehicle with standard error (SEM); CV=coefficient of variation; R=Rank from 4 comparisons (2x2 matrix); DN=effect of 50 MOI ad-DN-Nrf2 on gene expression changes induced by tBHQ. Gene functions were assessed using SwissProt and PubMed searches]. (N/R indicates that the gene did not pass rank; *the gene was significantly inhibited by DN, but still passed rank; if other than N/R, the fold change in the presence of DN is shown). Genes of interest that did not pass FC (?1.5 increased or 3 decreased) or had a CV?1.0 have the values shown in bold. Gene names in bold indicate genes that have already been shown or postulated to be ARE-driven (Rushmore, 2002; Moehlencamp et al., 1999; Lee et al., 2003; Li et al., 2002a; Murphy et al., 1991 and 2002; Shih et al., 2003).
