The Journal of Neuroscience, April 13, 2005, ():
Torsin-Mediated Protection from Cellular Stress in the Dopaminergic Neurons of Caenorhabditis elegans
J. Neurosci. Cao et al.
25: 3801
Supplemental data
Files in this Data Supplement:
- supplemental material
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Figure S1. Effects of torsin and CAT-2 overexpression in DA neurons at different developmental stages as animals age. Percentage of worms preserving all four wild type CEP neurons at larval stages L1/L2, L3/L4, and in 7-day-old adults was calculated for each of five CAT-2 overexpressinglines (n= 30-40 per stable line). TOR-2 is depicted as solid red circles, torsinA as open black circles, TOR-2(D367) as solid green triangles, torsinA(DE302/303) as open purple triangles, and CAT-2 alone as solid blue squares. Statistical significance between Pdat-1:: CAT-2 and comparison of the four torsin/CAT-2 overexpressing lines was assessed by the ANOVA Bonferroni test at all developmental stages; no significance was observed.
- supplemental material
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Figure S2. Effects of torsin and a-synuclein overexpression in DA neurons at different developmental stages as animals age. Percentage of worms preserving all four wild type CEP neurons at larval stages L1/L2, L3/L4, and in 7-day-old adults was calculated for each of five a-synuclein overexpressing lines (n= 30-40 per stable line). TOR-2 is depicted as solid red circles, torsinA as open black circles, TOR-2(D367) as solid green triangles, torsinA(DE302/303) as open purple triangles, and a-synuclein alone as solid blue squares. Statistical significance between Pdat-1:: a-synuclein and each of the four torsin/a-synuclein overexpressing lines was assessed by the ANOVA Bonferroni test at all developmental stages (*p < 0.05 for both TOR-2 and torsinA at the 7-day-old stage).
