The Journal of Neuroscience, May 11, 2005, ():
GABA Type-A Activity Controls Its Own Developmental Polarity Switch in the Maturing Retina
J. Neurosci. Leitch et al.
25: 4801
Supplemental data
Files in this Data Supplement:
- supplemental material
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Movie 1
Spontaneous wave of activity in the RGC layer in a S24 retina. Cells were back-labeled with calcium green dextran. The background fluorescence has been subtracted from the images, so that only increases in fluorescence, associated with Ca2+ and electrical activity are visible (played back in real time). The waves are fast and widespreading.
- supplemental material
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Movie 2
Spontaneous activity in the RGC layer of a 28 days post-hatching retina. The activity is much weaker than at earlier developmental stages. There are no propagating waves anymore, and few near-neighbor correlations.
- supplemental material
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Movie 3
Spontaneous activity in the RGC layer of a 28 days post-hatching retina that has been exposed to bicuculline from S24. The activity is stronger than in age-matched controls (see Movie 2) and exhibits propagating, wave-like patterns.
