The Journal of Neuroscience, January 12, 2005, ():
L1-Mediated Branching Is Regulated by Two Ezrin-Radixin-Moesin (ERM)-Binding Sites, the RSLE Region and a Novel Juxtamembrane ERM-Binding Region
J. Neurosci. Cheng et al.
25: 395
Supplemental data
Files in this Data Supplement:
- supplemental material -
Supplemental Table.
- supplemental material
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Supplementary figure 1 - Model for L1-mediated neurite outgrowth
L1 expressed on the cell surface binds to immobilized substrate L1 through homophilic interactions and then binds to another unknown coreceptor on the cell surface. The ERM-binding site on the L1 cytoplasmic domain couples L1 to the actin cytoskeleton and regulates branching. The unknown coreceptor may also be coupled to the actin cytoskeleton.
- supplemental material
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Supplementary figure 2. CGN neuron growing on L1, stained with anti-L1 antibody (A) and anti-activated ERM antibody (B). Some growth cones and minor neurites (white arrow) co-express activated ERM and L1 and others do not (red arrow). C) Merged image.
