The Journal of Neuroscience, June 15, 2005, ():
Synaptic Tagging and Cross-Tagging: The Role of Protein Kinase M
in Maintaining Long-Term Potentiation But Not Long-Term Depression
J. Neurosci. Sajikumar et al.
25: 5750
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplemental material. Role of PKMζ in synaptic tagging and cross-tagging during LTP and LTD in a CA1 pyramidal neuron.
Hypothesis of the activity-dependent synthesis of a pool of PRPs that are either specific for LTP (red triangles), specific for LTD (blue trapezoids), or non-specific (mixed red and blue trapezoids). PKMζ is the first identified LTP-specific PRP. PDE4B3 is the first known non-specific PRP, which could be also important for process-specific aspects such as the regulation of the synthesis of process-specific PRPs (Ahmed and Frey, 2003; Navakkode et al. 2004; Ahmed at al., 2004). An LTD-specific PRP has yet to be identified. Interestingly, the LTP-specific PRP PKMζ has dual functions - it is required for maintaining LTP and for the induction processes of LTP and LTD (red triangle on the base of the tagged synapse, in which we suppose that PKMζ activity required for the induction of the plastic events does not require de-novo synthesis of the molecule). We suggest that not only does the process-specific tag consist of a complex machinery of molecules specific for LTP (red symbol at the synapse) or LTD (blue symbol at the synapse) (Frey and Morris, 1998; Sajikumar and Frey, 2004), but also PRPs represent a pool of proteins expressing their effector roles by selective interactions with these process-specific tag complexes, in addition to basic short-term plasticity functions.
D1 - dopaminergic D1/D5-receptor; Glu- glutamatergic synapse.
