QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 15, 2005, ():

This Article Abstract Full Text Submit an eLetter Services Email this article to a friend Alert me to new issues of the journal

Visualization of Prion Infection in Transgenic Mice Expressing Green Fluorescent Protein-Tagged Prion Protein
J. Neurosci. Barmada and Harris 25: 5824

Supplemental data

Files in this Data Supplement:

• supplemental material - SUPPLEMENTAL FIGURE 1: Schematic diagram depicting the behavior of PrP-EGFP and its interaction with PrPSc in scrapie-infected mice. (A) In wild-type (Prn-p+/+) mice, endogenous PrPC is converted to PrPSc. (B) In Tg(PrP-EGFP+/+)/Prn-p0/0 mice, PrP-EGFP cannot be converted to PrPSc-EGFP. (C) In Tg(PrP-EGFP+/0)/Prn-p+/+mice, PrP-EGFP binds to PrPSc formed from endogenous PrPC, and competes with endogenous PrPC for access to PrPSc, thereby slowing the conversion process. Because it is incorporated into growing deposits of PrPSc, PrP-EGFP marks the microscopic location of PrPSc in the brain.

This Article Abstract Full Text Submit an eLetter Services Email this article to a friend Alert me to new issues of the journal

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help