The Journal of Neuroscience, June 29, 2005, ():
Brain-Derived Neurotrophic Factor Is Required for the Establishment of the Proper Number of Dopaminergic Neurons in the Substantia Nigra Pars Compacta
J. Neurosci. Baquet et al.
25: 6251
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplemental Figure 1 Neuronal processes in the dorsal lateral striatum
Wnt-BDNFKO and heterozygous mice appear to less dense fiber innervation in the dorsal lateral striatum than wildtype. Images were taken from sagittal sections of P21 mice using a 63X objective oil immersion lens and polarizing filter. Scale bar equals 50µm.
- supplemental material
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Supplemental Figure 2 Calbindin expression in wild-type and mutant mice
Comparison of images of the SNC from mutant and control genotypes shows the size of the substantia nigra pars reticulata appears reduced and the intensity of calbindin expression lessened in mutants compared to controls. The most anterior section is on the left and the most posterior on the right. Midline of a section is on the right of the image. Sections in upper panels stained for TH are adjacent and posterior to lower panel sections stained for calbindin.
- supplemental material
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Supplemental Figure 3 Calretinin expression in wild-type and mutant mice
Although there was no significant reduction in calretinin(CR)-expressing cells in the SNC, comparison of CR expression between genotypes as shown in the last two columns of images suggests a possible reduction in the number of CR-positive cells within the substantia nigra pars reticulata. The most anterior section is on the left and the most posterior on the right. Midline of a section is on the right of the image. Sections in upper panels stained for TH are adjacent and posterior to lower panel sections stained for CR.
