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The Journal of Neuroscience, January 19, 2005, ():

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Synaptic Targeting of Retrogradely Transported Trophic Factors in Motoneurons: Comparison of Glial Cell Line-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor, and Cardiotrophin-1 with Tetanus Toxin
J. Neurosci. Rind et al. 25: 539

Supplemental data

Files in this Data Supplement:

  • supplemental material - Supplemental Figure 1. Summarizing cartoon of trafficking of retrogradely transported trophic factors destined for degradation in the cell body (CT-1) or for additional dendritic and synaptic targeting (GDNF/BDNF). Dendritic trafficking entails accumulation in multivesicular bodies (MVBs), targeting to postsynaptic sites, and recycling across the synaptic cleft and/or transynaptic transcytosis and retrograde movement to second-order afferentneurons. Solid lines/arrows: synaptic targeting and recycling pathway; stippled arrows: degradation pathway.



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