The Journal of Neuroscience, August 3, 2005, ():
Homosynaptic and Heterosynaptic Inhibition of Synaptic Tagging and Capture of Long-Term Potentiation by Previous Synaptic Activity
J. Neurosci. Young and Nguyen
25: 7221
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplemental Figure 1. Schematic model detailing metaplastic effects of prior LFS on synaptic capture of L-LTP. (A) One-train (weak; one arrowhead) tetanus can generate a synaptic tag (*) but elicits only transient E-LTP. (B) Four-train (strong; four arrowheads) tetanus: 1) activates transcription (~); and 2) generates a synaptic tag (*) that permits capture of plasticity-relatedproteins (PRPs; triangles). This results in input-specific L-LTP expression that is immune to Dpt. (C) One-train tetanus at one set of inputs (S2) can capture PRPs activated by strong synaptic activity (e.g., four-train tetanus) at separate inputs (S1) to gain persistent L-LTP expression and immunity to Dpt. (D) Blocking transcription with Act D impairs L-LTP expression at S1 and S2. (E) Prior LFS (rectangle at S1) does not affect transcription but impairs synaptic tagging, and capture of L-LTP expression at S1. Subsequent one-train tetanus in S2 can generate a synaptic tag and capture PRPs for L-LTP expression and immunity to Dpt at S2. (F) LFS (rectangle at S2) given just prior to weak stimulation of S2 (single arrowhead) prevents synaptic tagging, capture of L-LTP PRPs, and acquisition of immunity to Dpt in S2.
