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The Journal of Neuroscience, August 24, 2005, ():

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Regulation of Human Recombinant P2X₃ Receptors by Ecto-Protein Kinase C
J. Neurosci. Wirkner et al. 25: 7734

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Supplemental Material

Files in this Data Supplement:

• Supplemental Fig. 1 - Supplementary Fig. Schematic drawing demonstrating the suggested modulatory effects of UTP at HEK293-hP2X3 cells. UTP may activate G protein-coupled P2Y receptors and thereby depress the sensitivity of P2X3 receptors towards their agonists. This negative receptor-receptor interaction may be blocked by the intracellular application of the stable GDP analogue GDP-?-S. UTP may also act as a substrate for an ecto-protein kinase (PKC) which phosphorylates Ser and/or Thr residues in consensus phosphorylation sites of the ectodomain of the P2X3 receptor. The relevant amino acids are indicated. -, negative interaction; +, positive interaction; G?,?,?, subunits of the G protein coupled to a P2Y receptor.

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