The Journal of Neuroscience, August 24, 2005, ():
Subthalamic Neurons Coordinate Basal Ganglia Function through Differential Neural Pathways
J. Neurosci. Yasoshima et al.
25: 7743
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Supplemental Material
Files in this Data Supplement:
- Supplemental Fig. 1
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Supplemental Figure 1. Possible models of the neural circuitry that mediates spontaneous and DA-induced motor behavior through the STN. The glutamatergic and GABAergic pathways are illustrated by blue and red lines terminating with triangles and bars, respectively. A,B, Basal state of the neural circuitry. Open arrows indicate the regulation of neural activity under the cell-ablation condition (A) relative to that under the normal condition (B). The STN neurons normally act to facilitate the output activity mainly through the subthalamonigral pathway (green arrow in B) and thereby suppress spontaneous locomotion. C-E, DA-induced state of the neural circuitry. Closed arrows indicate the regulation of neural activity after DA stimulation, and the number of the arrows represents the relative strength of the activity between the cell ablation (C) and normal (D) conditions. Pharmacological block of the GP activity by NBQX inhibits DA-induced suppression of the output activity and reduces motor activation (E). Gray arrows show the inhibitory influence on the output neurons through the activation of the striatonigral direct pathway. Normally, the STN activation, in response to DA stimulation, causes upregulation of the GP activity through the subthalamopallidal pathway and in turn suppresses the output activity through the pallidonigral pathway (green arrows in D), leading to DA-induced hyperactivity.
