The Journal of Neuroscience, August 31, 2005, ():
MONaKA, a Novel Modulator of the Plasma Membrane Na,K-ATPase
J. Neurosci. Mao et al.
25: 7934
Supplemental data
Files in this Data Supplement:
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Supplemental Figure 1. MONaKA sequences and splice variants. (A) Alignment of the deduced amino acid sequences of Drosophila slob (dSlob) and full-length human and mouse MONaKAs (hMONaKA and mMONaKA). The boxed regions represent regions of sequence identity common to all three proteins (about 33% identity). Mouse and human MONaKAs exhibit more than 90% identity to one another. MONaKA contains an unusual number of proline residues (red), often clustered together. The vertical arrow identifies the point at which a 33 nucleotide cassette is spliced into MONaKA mRNA to produce the shorter splice variant (see B). (B) Conserved splicing in human and mouse MONaKA. A 33 nucleotide cassette that encodes two stop codons (asterisks) is inserted immediately upstream of the region encoding the longest polyproline motif in full-length MONaKA. This splice variant produces a smaller protein, lacking the long polyproline motif.
