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The Journal of Neuroscience, August 31, 2005, ():

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Structural Determinants of Benzodiazepine Allosteric Regulation of GABAA Receptor Currents
J. Neurosci. Jones-Davis et al. 25: 8056

Supplemental data

Files in this Data Supplement:

  • supplemental material - Supplemental Figure 1. Peak amplitude response of wild-type, chimeric, and mutant subunits in response to 1 ?M GABA. For a given subunit, EC20 ± 10 GABA (1 ?M GABA) evokes currents of variable amplitude in wild-type ?1?3?2L, ?1?3?, chimeric, and mutant subunits. For ?1?3?-?M1, 10 ?M GABA was used and for ?1?3?V290A+Y292A+V293I+T294K 3 ?M GABA was used, as these chimeras were found to have significantly different responses to 1 ?M GABA than the other subunits.




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