The Journal of Neuroscience, September 7, 2005, ():
Ionic Mechanisms Underlying Autonomous Action Potential Generation in the Somata and Dendrites of GABAergic Substantia Nigra Pars Reticulata Neurons In Vitro
J. Neurosci. Atherton and Bevan
25: 8272
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure. Hyperpolarization-activated currents recorded in the perforated patch configuration
A1-2, Example of perforated patch voltage-clamp recordings in the presence of 1 µM TTX showing a family of currents evoked by 1 s hyperpolarizing steps from a holding potential of –50 mV. At the most hyperpolarized potentials a slowly activating inward current was evoked (A1, A3) that could be blocked by 20 µM ZD7288 (A2, A3). A3, I-V plots of the early (open symbols) and late (filled symbols) currents recorded from the cell shown in A1, A2. The early control currents (open black squares) overlay almost exactly with both the early (open grey circles) and late (filled gray circles) currents measured in ZD7288. B, Mean ZD 7288-sensitive I-V relationship in 6 cells.
