The Journal of Neuroscience, September 14, 2005, ():
Enhancement of Excitatory Synaptic Integration by GABAergic Inhibition in the Subthalamic Nucleus
J. Neurosci. Baufreton et al.
25: 8505
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. HCN channels do not participate in the resetting of autonomous activity by synaptically evoked or dIPSPs
A-B, Representative examples of the minimal effects of ZD7288 on the resetting ofautonomous activity by IPSPs or dIPSPs. A(i-ii), Superimposition of 20 trials showing resetting by stimulated IPSPs in control conditions (A(i)), and in the presence of 20 µM ZD7288 (A(ii)). The vertical deflection immediately before the onset of the IPSP is the electrical stimulation artifact. B(i-ii), Superimposition of 50 trials of resetting by dIPSPs in control conditions (B(i)), and in the presence of 20 µM ZD7288. (B(ii)).
- supplemental material
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Supplementary Figure 2. Somatic dIPSPs modify the morphologies of APs
Single dIPSPs (i) lowered APth (ii-iv) and increased the maximal speed of APs (iii-iv) generated after a dIPSP. (ii), overlaid APs generated before (AP -1) and after a dIPSP (AP 1). (iii), Phase plot showing the shift in APth. Insets, zoom of APths (dots). (iv), Population sample of the change in APth and maximal speed of APs (n = 13) for single (black) and multiple dIPSPs (red). Larger effects were observed in individual neurons (not shown) and across the population sample (iv) after multiple IPSPs. *, denotes P < 0.05.
