The Journal of Neuroscience, September 28, 2005, ():
Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
J. Neurosci. Jin et al.
25: 9027
Supplemental data
Files in this Data Supplement:
- supplemental material -
Supplemental data. Protein alignment of representative glutamate receptors. A Clustal alignment of the primary amino acid sequence of the ligand-binding core of AMPA, kainate, and NMDA glutamate receptors. Scissors indicate from which regions the isolated ligand-binding core was formed. Domains I (dark blue) and II (light blue) together form the clamshell conformation. The hinge regions (I and II) are shown in red. Point mutations studied are indicated in bold, with their sequence number shown above the alignment. Transmembrane domains are boxed with solid lines; the flip/flop alternative splice site is shown boxed with a broken line.
