The Journal of Neuroscience, October 19, 2005, ():
Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease
J. Neurosci. Marti et al.
25: 9591
Supplemental data
Files in this Data Supplement:
- supplemental material
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Figure 1S. Mice lacking the NOP receptor (NOP-/-) are more resistant to haloperidol-induced catalepsy than wild-type (NOP+/+) controls. Mice were treated with haloperidol 1.5 and 3 mg/Kg (i.p.) and akinesia measured for up to 8 hr by using the bar (A-B), drag (C-D) and rotarod (E-F) test. Data are expressed as means ± SEM of 12-24 determinations obtained from 44 NOP-/- and 44 NOP+/+ mice.
**P<0.01, versus control.
°P<0.05, °°P<0.01, versus NOP+/+ mice (ANOVA followed by Newman-Keuls post hoc test)
- supplemental material
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Figure 2S. Schematic representation of microdialysis probe location in the SNr (AP -5.3 from bregma). Data are referred to Experiment #5. The triangles represent the location of the tip of the probe.
