The Journal of Neuroscience, November 2, 2005, ():
Neuronal L-Type Calcium Channels Open Quickly and Are Inhibited Slowly
J. Neurosci. Helton et al.
25: 10247
Supplemental data
Files in this Data Supplement:
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Supplemental Figure. CaV1.3, CaV3.1 and CaV2.2 channels can support calcium influx during action potential waveform stimulation. a, Normalized CaV1.3, CaV1.2 and CaV2.2 current traces evoked by action potential waveforms recorded from a cerebellar Purkinje neuron. b, Normalized CaV1.3, CaV3.1 and CaV2.2 current traces evoked by action potential waveform recorded from a sympathetic neuron. Vertical bar next to each waveform corresponds to 40 mV. The time course of CaV1.3 and CaV2.2 channel currents is similar. CaV3.1 channel currents activate with a slightly longer delay and continue to support calcium entry for several ms after the end of the stimulus. c, Average delay between the peak of the command voltage and the peak inward current for each current. Time intervals were for CaV3.1: 0.86 ± 0.04 ms (n=8); CaV1.3: 0.62 ± 0.01 ms (n=10); and CaV2.2: 0.63 ± 0.05 ms (n=8). * denotes statistically significant difference between CaV3.1 and CaV1.3 (student’s paired t-test, p<0.001).
