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The Journal of Neuroscience, November 9, 2005, ():

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Src-Family Kinases Stabilize the Neuromuscular Synapse In Vivo via Protein Interactions, Phosphorylation, and Cytoskeletal Linkage of Acetylcholine Receptors
J. Neurosci. Sadasivam et al. 25: 10479

Supplemental data

Files in this Data Supplement:

  • supplemental material - Supplementary Figure 1. Src and Fyn are required to stabilize clusters of α-dystrobrevin, rapsyn and utrophin along with AChR clusters. Myotubes were incubated overnight with 0.5 nM agrin following which agrin was withdrawn for 5 h. Cells were double labeled for the AChR with α-BT-rhodamine and for the respective postsynaptic proteins. In src-/-;fyn-/- myotubes clusters of α-dystrobrevin-1 (α-DB), rapsyn (Rap), and utrophin (Utro) disperse in parallel with the AChR clusters. In wild-type cells clusters of AChRs and postsynaptic proteins remain stable.



This Article
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