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The Journal of Neuroscience, November 9, 2005, ():

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Dopamine Modulation of State-Dependent Endocannabinoid Release and Long-Term Depression in the Striatum
J. Neurosci. Kreitzer and Malenka 25: 10537

Supplemental data

Files in this Data Supplement:

  • supplemental material - Supplemental Figure 1. Model of eCB-LTD at excitatory synapses onto medium spiny neurons Activation of postsynaptic mGluR1/5, along with coincident subthreshold depolarization of medium spiny neurons sufficient to activate L-type voltage-sensitive calcium channels (VSCCs), stimulates the postsynaptic synthesis and release of endocannabinoids, perhaps via PLCβ (Hashimotodani et al., 2005). Co-activation of postsynaptic dopamine D2-type receptors (D2R) enhances endocannabinoid production and the subsequent induction of presynaptic LTD, mediated through activation of presynaptic CB1 receptors (CB1R).




This Article
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