The Journal of Neuroscience, November 16, 2005, ():
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
J. Neurosci. Ramsden et al.
25: 10637
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplemental Figure 1. Absence of pathological tau epitopes in control brain tissue. This figure represents a mirror image of the panel of representative IHC photomicrographs shown in Figure 2. No positive labeling was observed in age-matched transgenic control mice following identical parallel immunohistochemical processing with MC-1, CP-13, AT-8, PG-5, TG-3 or PHF-1.
- supplemental material
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Supplemental Figure 2. Spatial navigation in the hidden platform and performance in the cued platform phase of water maze testing. Path lengths in the hidden platform and cued platform (visible) phases of the water maze as a function of training trial (each data point represents a mean of 4 or 3 trials for the hidden and visible platforms respectively). N numbers; 1.3-month old mice (n=31 control and n=10 rTg(tauP301L)4510), 2.5 to 9.5-months (n=26 control and n=9 rTg(tauP301L)4510) #P<0.05, ◊P<0.01, *P<0.001, **P<0.0001. In all panels, open circles represent Tau-neg and closed circles Tau-pos mice, respectively.
