The Journal of Neuroscience, November 16, 2005, ():
Mitogen-Activated Protein Kinase-Mediated Reinforcement of Hippocampal Early Long-Term Depression by the Type IV-Specific Phosphodiesterase Inhibitor Rolipram and Its Effect on Synaptic Tagging
J. Neurosci. Navakkode et al.
25: 10664
Supplemental data
Files in this Data Supplement:
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Schematic illustration of the possible action of rolipram (modified from data provided by Sweatt, 2001; Altschuler and Ribeiro-Neito, 1998; Waltereit and Weller, 2003) during LTD, i.e., during the transformation of early-LTD into late-LTD in hippocampal CA1 from adult rats.
Induction of electrically induced early-LTD by field electrodes in hippocampal CA1 neurons from adult rats activates glutamatergic NMDAR, as well as dopaminergic D1/D5-receptors. For RLTD we could exclude the NMDAR-PKC/Ras mediated activation of MAKP/ERK. The interaction of NMDAR-mediated Ca2+/calmodulin-initiated processes with dopaminergically induced processes remain speculative but we favour a role in marking/tagging the synapse for LTD. D1/D5-receptor-dependent processes mediate a cAMP/PKA-dependent, Rap1/B-Raf-mediated activation of MAPK/ERK, resulting in protein synthesis and the transformation of early-LTD into late-LTD. For further explanation see the discussion section.
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