The Journal of Neuroscience, December 7, 2005, ():
Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation
J. Neurosci. Premkumar et al.
25: 11322
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. PKC activation phosphorylates TRPV1 and potentiates currents. a, Potentiation of currents induced by protons and capsaicin after incubation of oocytes with PDBu (1μM) for 5 min. b, In a double phosphorylation site TRPV1 mutant the potentiation is drastically reduced. c, Summary graph showing the potentiation of TRPV1 current by PDBu (p<0.01), which is reduced dramatically in a double phosphorylation site mutant.
