The Journal of Neuroscience, December 7, 2005, ():
Parsing Molecular and Behavioral Effects of Cocaine in Mitogen- and Stress-Activated Protein Kinase-1-Deficient Mice
J. Neurosci. Brami-Cherrier et al.
25: 11444
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1: Brain morphology in MSK1 knockout mice. Brain morphology was analyzed using cresyl violet staining in several brain regions of wild type (wt) and MSK1 knockout (ko) mice. (a) Hippocampus (scale bar: 450 µm). (b) Dentate gyrus (scale bar: 70µm). (c) Cerebellum (upper panel: scale bar: 240 µm, lower panel: scale bar 120 µm). (d) Nucleus accumbens (scale bar: 35 µm). No evident neuronal alteration was found in these brain regions of MSK1-KO mice.
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Supplementary Figure 2: Circadian locomotor activity of MSK1 knockout mice. Horizontal locomotor activity (a) and rearing behavior (vertical locomotor activity) (b) throughout the light/dark cycle were measured for 24 hours wild type (wt) and MSK1 knockout (ko) mice, with activity recorded every 30 min. The solid bars indicate the dark cycle (n = 10-12).
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Supplementary Figure 3: Locomotor activity induced by D1 and D2 agonists in MSK1 knockout mice. Time course of the effects of a D1 agonist, 6-chloroPB (3 mg/kg, i.p.) (a) and a D2 agonist, quinpirole (1 mg/kg, i.p.) (b) on the locomotion of wild type (wt) and MSK1 knockout (ko) mice. The locomotor activity was recorded every 5 min.
