The Journal of Neuroscience, December 14, 2005, ():
A C-Terminal Domain Directs Kv3.3 Channels to Dendrites
J. Neurosci. Deng et al.
25: 11531
Supplemental data
Files in this Data Supplement:
- supplemental material -
Supplemental Methods
- supplemental material
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Figure S1: Currents recorded from aptKv3 channels and recombinant constructs expressed in CHO cells. Comparison of unmodified AptKv3.1 or Apt Kv3.3 (top panels) with recombinant chimeric or deletion mutant constructs prepared for viral injection and recombinant expression in ELL pyramidal neurons. Titles for each construct correspond to the schematic illustrations provided in Figure 4.
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Figure S2: The C terminal, but not the N terminal segment of Kv3.3 is required for channel localization to distal dendrites of pyramidal neurons. A, B, AptKv3 channels with deletions of the C-terminal segments are restricted to somas and proximal dendrites of ELL pyramidal neurons. C, D, Exchange of the N-terminal domains of the two AptKv3 channels does not alter their targeting phenotype.
