The Journal of Neuroscience, January 4, 2006, ():
Miniature Synaptic Events Elicited by Presynaptic Ca2+ Rise Are Selectively Suppressed by Cannabinoid Receptor Activation in Cerebellar Purkinje Cells
J. Neurosci. Yamasaki et al.
26: 86
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplemental Figure 1
Concentration-dependent effect of WIN55,212-2 on mEPSC and mIPSC.
(A). Ca2+-enhanced mEPSC is selectively suppressed by WIN55,212-2 in a dose-dependent manner. WIN55,212-2 with two to four different concentrations was applied sequentially to the same PC from lower to higher concentrations. Each symbol represents mean ± SEM. Miniature EPSCs were recorded with 0 mM Ca2+o (open circle, n = 2-6), with 2 mM Ca2+o (filled circle, n = 2-6), and with 5 mM Ca2+o (filled rectangle, n = 4-7).
(B). Ca2+-enhanced mEPSC is selectively suppressed by WIN55,212-2 in a dose-dependent manner. Data are illustrated similarly to A. Miniature IPSCs were recorded with 0 mM Ca2+o + BAPTA-AM (open circle, n = 2-6), with 2 mM Ca2+o (filled circle, n = 4-8), and with 5 mM Ca2+o (filled rectangle, n = 4-8).
