The Journal of Neuroscience, March 8, 2006, ():
Glial Cell Line-Derived Neurotrophic Factor-Dependent Recruitment of Ret into Lipid Rafts Enhances Signaling by Partitioning Ret from Proteasome-Dependent Degradation
J. Neurosci. Pierchala et al.
26: 2777
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplemental Figure 1: The mechanism of Ret activation and downregulation in sympathetic neurons is shown schematically.
Formation of the GDNF-GFRα1-Ret signaling complex results in the translocation of Ret from non-raft domains into lipid raft membrane domains. Ret then moves out of lipid rafts, either alone or as a stable ligand-receptor complex, where it is ubiquitinated. The ubiquitinated Ret is then degraded predominantly by the proteasome.
