The Journal of Neuroscience, March 15, 2006, ():
Development of the Deep Cerebellar Nuclei: Transcription Factors and Cell Migration from the Rhombic Lip
J. Neurosci. Fink et al.
26: 3066
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. Reelin (green) expression was preserved in Tbr1–/– mutants. As compared to controls (A, C), Tbr1 mutants (B, D) showed no defects of reelin expression on E13.5 (A, B) and E16.5 (C, D). Scale bar: (in A) 100 µm.
- supplemental material
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Supplementary Figure 2. Model for cerebellar neurogenesis, with compartmentalization of glutamatergic and GABAergic neuron progenitors. The rhombic lip produces glutamatergic neurons, i.e., DCN projection neurons, granule neurons, and unipolar brush cells (UBCs); the cerebellar plate VZ produces GABAergic neurons, i.e., Purkinje cells and inhibitory interneurons (of which there are numerous subtypes). Different transcription factor genes are expressed in each compartment: Ptf1a in the cerebellar VZ (Hoshino et al., 2005), and Math1 and Pax6 in the rhombic lip (Engelkamp et al., 1999; Wang et al., 2005; present study). The migrations of rhombic lip–derived cells are particularly complex, including not only subpial migration to the nuclear transitory zone (NTZ) and external granular layer, but also migration of unipolar brush cells directly into the developing white matter (C. Englund and R. Hevner, unpublished observations).
