The Journal of Neuroscience, March 29, 2006, ():
Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury
J. Neurosci. Karimi-Abdolrezaee et al.
26: 3377
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. Survival of grafted NPCs in sub-acutely injured spinal cord without growth factor treatment. A Low magnified confocal image from a longitudinal section of injured spinal cord shows the extent of YFP-NPCs survival within the injured spinal cord without growth factor infusion at six weeks post-transplantation. In contrast to the enhanced survival of grafted NPCs after treatment with growth factor cocktail (Fig.3), we observed a very poor survival of NPCs in the injured spinal cord of transplanted rats that received no growth factors.
- supplemental material
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Supplementary figure 2. Transplantation of adult NPCs in Chronic SCI. (A-C) the presence of surviving YFP-NPCs in a subset of chronically transplanted injured rats, at two weeks post-transplantation. At later time points three weeks (D-F) and six weeks (G-I), we only observed a large number of auto-fluorescence profiles in the injured spinal cord, which likely reflected the presence of dead grafted cells. F and I (the magnified boxed areas in E and H, respectively) show the presence of clusters of dead cells in the vicinity of the implantation sites suggesting that the lack of cell migration and integration may have contributed to the poor cell survival after chronic SCI
