The Journal of Neuroscience, April 5, 2006, ():
Membrane-Proximal Region of Glutamate Receptor 
2 Subunit Is Critical for Long-Term Depression and Interaction with Protein Interacting with C Kinase 1 in a Cerebellar Purkinje Neuron
J. Neurosci. Yawata et al.
26: 3626
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Hypothetical model about the role of PICK1-GluRδ2 interaction in the induction of LTD. (1) GluR2 containing AMPA receptor is anchored by GRIP and PICK1 by GluRδ2 at the postsynaptic membrane of a parallel fiber-PN synapse. (2) PKC activated by the conditioning stimulation binds to PICK1 and phosphorylates Ser880 residue of GluR2. At this stage, GluRδ2 helps efficient interaction between PICK1, PKC and GluR2 by anchoring PICK1 and PKC. (3) Phosphorylation of the Ser880 residue releases the GluR2 containing AMPA receptor from GRIP. Then, GluR2 binds to PICK1. (4) PICK1 facilitates internalization of the GluR2 containing AMPA receptor. Thus, the number of AMPA receptors at the postsynaptic membrane is reduced, resulting in the depression of glutamate responsiveness. GluR subunits comprising AMPA receptor together with GluR2 are not shown for simplicity.
