The Journal of Neuroscience, April 5, 2006, ():
Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of 
-Synucleinopathy
J. Neurosci. von Coelln et al.
26: 3685
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Supplemental Figure 1: Fluoro Jade B staining in pathologically affected regions of human A53T α-synuclein transgenic mice with or without parkin colocalizes with cells that stain positive for α-synuclein and GFAP. Sagittal brain sections at the level of brain stem of mice sacrificed at the terminal stage of α-synuclein-induced disease and age-matched non transgenic mice with or without parkin were analyzed for the distribution of Fluoro Jade B, α-synuclein and GFAP. (A) Fluoro Jade B and GFAP positive cells are abundant in human A53T α-synuclein transgenic mice with or without parkin. Fluoro Jade B positive cells colocalize or are in close apposition with GFAP positive cells suggesting that reactive glia stains for Fluoro Jade B. (B) Fluoro Jade B and α-synuclein positive cells are abundant in human A53T α-synuclein transgenic mice with or without parkin. All the Fluoro Jade B positive cells colocalize with α-synuclein positive cells suggesting that neurons positive for α-synuclein inclusions stain for Fluoro Jade B (Scale bar: 20 μm).
