The Journal of Neuroscience, April 5, 2006, ():
Cortical Inputs and GABA Interneurons Imbalance Projection Neurons in the Striatum of Parkinsonian Rats
J. Neurosci. Mallet et al.
26: 3875
Supplemental data
Files in this Data Supplement:
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Supplemental Figure Coronal section of the forebrain immunolabelled with antibodies directed against tyrosine hydroxylase (TH) and parvalbumin. Double-immunolabeling for tyrosine hydroxylase (TH, stained in brown with DAB alone) and for parvalbumin (stained in black with DAB amplified by nickel) was used as a control both for the effectiveness of the 6-OHDA lesion and for the density of parvalbumin positive neurons in the denervated striatum. Note the complete disappearance of TH-positive fibers in the striatum ipsilateral to 6-OHDA injection, and the increasing density gradient of parvalbumin-positive cell bodies from medial to lateral parts of both striatum. Dopaminergic depletion did not affect the number of parvalbumin cells.
