The Journal of Neuroscience, April 12, 2006, ():
Tubulin-Mediated Binding of Human Immunodeficiency Virus-1 Tat to the Cytoskeleton Causes Proteasomal-Dependent Degradation of Microtubule-Associated Protein 2 and Neuronal Damage
J. Neurosci. Aprea et al.
26: 4054
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Figure 7 Schematic diagram of a model for Tat-induced MAP2 breakdown. MAP2 is normally associated with microtubules and contributes to the dynamic instability that is required for the survival and function of the nerve cells. The tubulin-binding domain of Tat might be involved in cytoplasmic retention of Tat both in vitro and in clinical samples. Proteasomes may be engaged and mobilized by Tat from the nucleus to the proximity of microtubules in the neuronal process, where they promote MAP2a/b degradation.
