The Journal of Neuroscience, April 19, 2006, ():
Overloading of Stable and Exclusion of Unstable Human Superoxide Dismutase-1 Variants in Mitochondria of Murine Amyotrophic Lateral Sclerosis Models
J. Neurosci. Bergemalm et al.
26: 4147
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1 Density gradient separation of homogenates of brains from a presymptomatic and a terminally ill G127X transgenic mouse by density gradient ultracentrifugation. Tissue homogenization, preparation of gradients, ultracentrifugation and analysis of fractions were carried out as described in Materials and Methods. A, a presymptomatic mouse and B, a terminally ill mouse.
- supplemental material
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Supplementary Figure 2 Density gradient separation of a homogenate of a kidney from a presymptomatic G85R hSOD1 transgenic mouse. Tissue homogenization, preparation of gradients, ultracentrifugation and analysis of fractions were carried out as described in Materials and Methods. The mitochondrial marker SDH and the human and murine SOD1s were analyzed in the tapped fractions.
