The Journal of Neuroscience, April 26, 2006, ():
The Dopamine D2 Receptor Regulates the Development of Dopaminergic Neurons via Extracellular Signal-Regulated Kinase and Nurr1 Activation
J. Neurosci. Kim et al.
26: 4567
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1.
The relative ratios of Tyrosine hydroxylase (TH) positive cells after treatment with 1-methyl-4-phenylpyridinium (MPP+) were presented. Percentages of MPP+ treated TH positive cell number (filled bar) based on control TH positive cell number (set at 100 %) from mesencephalic cultures of WT (n=5) and D2R-/- (n=7) embryonic mice, each as a percentage of its own control, after treatment with 1-10 µM of MPP+ are expressed as the mean ± SEM († p< 0.05, †† p< 0.01, and ††† p< 0.001 represents the result of unpaired students t-test for WT vs D2R-/- mice).
- supplemental material
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Supplementary Figure 2. Proposed signaling pathways and the role of mesencephalic dopamine receptor D2R in the development of mesencephalic dopaminergic neurons The stimulation of dopamine D2R induces the activation of ERK. Subsequently Nurr1 is activated by ERK, then activated-Nurr1 can induce TH gene expression in mesencephalic dopaminergic neurons. The inhibitors of MAPK signaling pathway and specific antagonist of D2R, which were used in this study, are indicated.
