The Journal of Neuroscience, May 3, 2006, ():
A Mechanism for Vocal-Respiratory Coupling in the Mammalian Parabrachial Nucleus
J. Neurosci. Smotherman et al.
26: 4860
Supplemental data
Files in this Data Supplement:
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Supplemental Figure: Overview of the proposed model of how laryngeal activation during vocalizing may postpone inspiratory onset via an inhibitory afferent feedback loop. Inhibitory connections: closed circles; excitatory connections: arrows. Respiratory phase-switching neurons in the lateral PB are hypothesized to be integrating multiple somatosensory influences on the time course of inspiration. While other identified forms of locomotor-respiratory coupling act via excitatory inputs to the lateral PB (Potts et al., 2004; Rybak et al., 2004), here we propose that laryngeal afferents act via inhibitory synapses to postpone inspiration during vocalizing. Feed-forward influences on respiratory rhythms during vocalizing are also suspected to exist in both the PB and medullary respiratory rhythm centers (not shown). Extensive reciprocal connectivity between the PAG and PB as well as between the PB and NA are known to exist but may play diverse roles in vocal motor patterning. PAG, periaqueductal grey; NA, nucleas ambiguous; PB lateral parabrachial nucleus; VRG, ventral respiratory group.
