The Journal of Neuroscience, May 10, 2006, ():
Translocation of Synaptically Connected Interneurons across the Dentate Gyrus of the Early Postnatal Rat Hippocampus
J. Neurosci. Morozov et al.
26: 5017
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Figure 8. Diagram of synaptic relationships of an interneuron during translocation of its soma from the stratum moleculare (sm) across the stratum granulosum (sg; indicated with dashed lines) to the final destination in the hilus of the dentate gyrus. The cells of types B, C and D represent stages of the interneuron’s mophogenetic transformation as illustrated in Figure 1. Type B cell receives inputs from the entorhinal cortex and/or contralateral hippocampus (*) and innervates the granule cell (g). While the cell becomes bipolar and moves into the granular layer (type C), its terminal boutons on the granule cell remain fixed, resulting in the formation of the characteristic axonal loop (al). Synaptic turnovers cannot be excluded which is indicated with synapses #1a and #1b. But we suggest that the inputs, such as synapse #2, remain attached to the same segment of the cell membrane, while the nucleus and surrounding cytoplasm translocate within the leading process to the hilus. Thus, initially perisomatic synapses on the type C cell, became dendritic, after the cell body moves to the hilus (type D). Elongation of axons and displacement of synapses to a new position (e.g. #2a), as marked by X, is unlikely. Notice that the cell of type B is not innervated by the granule cells but receives an occasional synapse after being transformed into type C (e.g., synapse #3) and finally acquires numerous synapses from granule cells after becoming type D (e.g., #3, #4 and #5). See the text for further explanation.
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