The Journal of Neuroscience, May 10, 2006, ():
Psychostimulant-Induced Attenuation of Hyperactivity and Prepulse Inhibition Deficits in Adcyap1-Deficient Mice
J. Neurosci. Tanaka et al.
26: 5091
Supplemental data
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Supplemental figure Schematic representation of possible relationships between locomotor activity and degree of stimulation of 5-HT1A systems, or relative balance between 5-HT1A and other 5-HT receptor subtypes or neurotransmitter systems. Adcyap1-/- mice were hyperactive in open field; however, hyperlocomotion was paradoxically attenuated by amphetamine (2 mg/kg). This antihyperkinetic effect of amphetamine depended on serotonin 5-HT1A receptor signaling; the selective 5-HT1A receptor antagonist WAY-100635 (0.3 mg/kg) blocked amphetamine action. Although amphetamine (2 mg/kg) increased locomotor activity in wild-type control mice, it produced paradoxical calming effect in wild-type mice that received the 5-HT1A agonist 8-OH-DPAT (0.05 mg/kg).
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