The Journal of Neuroscience, May 10, 2006, ():
Spectrins and AnkyrinB Constitute a Specialized Paranodal Cytoskeleton
J. Neurosci. Ogawa et al.
26: 5230
Supplemental data
Files in this Data Supplement:
- supplemental material
-
Figure S1. Immunostaining of Caspr -/- and Caspr2 -/- mice for Caspr (green) and βII spectrin (red) shows a pronounced gap in immunoreactivity at the node. Immunostaining between the Caspr -/- and Caspr2 -/- mice is indistinguishable. Scale bar = 5 µm.
- supplemental material
-
Figure S2. Proposed interactions between paranodal cell adhesion molecules and paranodal cytoskeletal proteins. The three polarized domains at and near the node of Ranvier have a common molecular organization: neuron-glia interactions through CAMs are stabilized and maintained by interactions with a specialized cytoskeleton comprised of ankyrins and spectrins.
