The Journal of Neuroscience, January 11, 2006, ():
Aldosterone Target Neurons in the Nucleus Tractus Solitarius Drive Sodium Appetite
J. Neurosci. Geerling et al.
26: 411
Supplemental data
Files in this Data Supplement:
- supplemental material
-
Supplemental Figure 1. The enzyme 11-β-hydroxysteroid dehydrogenase type 2 (HSD2) is required to make a cell selective for, and therefore sensitive to, the low circulating levels of aldosterone. (A) The plasma concentration of glucocorticoids, such as corticosterone, is always 100-1000x higher than that of aldosterone (ALDO). Since aldosterone and corticosterone bind the mineralocorticoid receptor (MR) with equal affinity (Sheppard and Funder, 1987), nearly all MR is bound by corticosterone in most cells, preventing aldosterone access. (B) Cells that express HSD2, such as principal cells in the distal nephron of the kidney, are selectively responsive to aldosterone. HSD2 converts 11-hydroxysteroids, such as corticosterone (CORT-OH), into 11-keto metabolites (CORT=O) that cannot bind and activate MR. This frees the receptor from occupation by glucocorticoids (Funder et al., 1988).
