The Journal of Neuroscience, May 17, 2006, ():
Ischemic Insults Direct Glutamate Receptor Subunit 2-Lacking AMPA Receptors to Synaptic Sites
J. Neurosci. Liu et al.
26: 5309
Supplemental data
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Supplementary Figure 1. Scheme of ischemia-induced internalization of GluR2-containing AMPARs. In the basal state, GluR2-containing AMPARs are stabilized at the postsynaptic membrane via association with ABP (1). Ischemic insults activate PKC and promote binding of PKC to PICK1, which in turn promotes targeting of the PICK1-PKC complex to the ABP-GluR2 complex (2). PICK1 competes with ABP for GluR2 binding (3), leading to disruption of GluR2 binding to ABP and enhanced association with PICK1. Association of GluR2-containing AMPARs with PICK1 promotes receptor internalization (4).
